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PD 407824

CAT: 0804-HY-18961-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18961-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2].
CAS Number
622864-54-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Checkpoint Kinase (Chk) ; Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pd-407824.html
Purity
99.00
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1NC(C2=C1C3=C(C=C2C4=CC=CC=C4)NC5=C3C=C(O)C=C5)=O
Molecular Formula
C20H12N2O3
Molecular Weight
328.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Palmer BD, et al. 4-Phenylpyrrolo[3,4-c]carbazole-1,3 (2H,6H) -dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem. 2006 Aug 10;49 (16) :4896-911.|[2]Feng L, et al. Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Cell Rep. 2016 May 31;15 (9) :2063-75.|[3]Smaill JB, et al. Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3 (2H,6H) -diones as inhibitors of Wee1 and Chk1 checkpointkinases. Eur J Med Chem. 2008 Jun;43 (6) :1276-96. Epub 2007 Aug 6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1

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