Bromocriptine (mesylate)

CAT: 0804-HY-12705A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12705A-01Size:5 mg
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Description
Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.
CAS Number
[22260-51-1]
Product Name Alternative
CB-154
UNSPSC
12352005
Hazard Statement
H400, H410
Target
Autophagy; Dopamine Receptor
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Bromocriptine-mesylate.html
Purity
99.98
Solubility
DMSO : 175 mg/mL (ultrasonic) |H2O : 1.1 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
[H][C@@]12CC3=C(Br)NC4=CC=CC(C1=C[C@@H](C(N[C@@]5(C(C)C)C(N6[C@@H](CC(C)C)C(N7CCC[C@]7([C@]6(O)O5)[H])=O)=O)=O)CN2C)=C43.OS(=O)(C)=O
Molecular Formula
C33H44BrN5O8S
Molecular Weight
750.70
Precautions
H400, H410
References & Citations
[1]Gardner B, et al. Agonist action at D2 (long) dopamine receptors: ligand binding and functional assays. Br J Pharmacol. 1998 Jul;124 (5) :978-84.|[2]Renodon A, et al. Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects.FEBS Lett. 1997 Apr 7;406 (1-2) :33-6.|[3]Wynalda MA, et al. Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen. Drug Metab Dispos. 1997 Oct;25 (10) :1211-4.|[4]Rana DG, et al. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. 2014 Jan;35 (1) :90-7.|[5]Dieb W, et al. Nigrostriatal dopaminergic depletion increases static orofacial allodynia. J Headache Pain. 2016;17:11.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D2 Receptor
Citation 01
Aquaculture. 2025 Apr 15.|bioRxiv. 2025 Oct 13.|BMC Endocr Disord. 2021 Nov 23;21 (1) :235.|Br J Pharmacol. 2021 Sep;178 (17) :3570-3586.|Eur J Integr Med. 2021, 101322.|Eur J Pharmacol. 2023 Jan 5:938:175443.|Int J Mol Sci. 2024 Nov 21;25 (23) :12483.|J Biomol Struct Dyn. 2022;40 (23) :12800-12811.|J Endocrinol Invest. 2025 Jan;48 (1) :67-80.|J Ethnopharmacol. 2021 Jun 12:273:113994.|Nat Commun. 2020 Feb 18;11 (1) :941. |Phytomedicine. 2025 Jun:141:156707.|Sci Adv. 2021 Nov 26;7 (48) :eabj4624.|Clin Immunol. 2025 Oct 14:281:110604.|Mol Pharm. 2022 Nov 7;19 (11) :4320-4332.|Pharmacogn Mag. 2023 Oct 12.|Toxicol Appl Pharmacol. 2024 Apr:485:116876.

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