Bromocriptine

• UNSPSC Description:

  Bromocriptine is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

• Target Antigen:

  Dopamine Receptor

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Bromocriptine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@@]12CC3=C(Br)NC4=CC=CC(C1=C[C@@H](C(N[C@@]5(C(C)C)C(N6[C@@H](CC(C)C)C(N7CCC[C@]7([C@]6(O)O5)[H])=O)=O)=O)CN2C)=C43

• Molecular Weight:

  654.59

• References & Citations:

  [1]Gardner B, et al. Agonist action at D2(long) dopamine receptors: ligand binding and functional assays. Br J Pharmacol. 1998 Jul;124(5):978-84.|[2]Renodon A, et al. Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects.FEBS Lett. 1997 Apr 7;406(1-2):33-6.|[3]Wynalda MA, et al. Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen. Drug Metab Dispos. 1997 Oct;25(10):1211-4.|[4]Rana DG, et al. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. 2014 Jan;35(1):90-7.|[5]Dieb W, et al. Nigrostriatal dopaminergic depletion increases static orofacial allodynia. J Headache Pain. 2016;17:11.Mol Pharm. 2022 Oct 21.|Pharmacogn Mag. 2023 Oct 12.|Toxicol Appl Pharmacol. 2024 Mar 2:116876.|BMC Endocr Disord. 2021 Nov 23;21(1):235.|Br J Pharmacol. 2021 Apr 26.|Eur J Integr Med. 2021, 101322.|Eur J Pharmacol. 2022: 175443.|Int J Mol Sci. 2024 Nov 21;25(23):12483.|J Biomol Struct Dyn. 2021 Sep 22;1-12.|J Endocrinol Invest. 2024 Jun 26.|J Ethnopharmacol. 2021 Mar 9;113994.|Nat Commun. 2020 Feb 18;11(1):941. |Sci Adv. 2021 Nov 26;7(48):eabj4624.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  25614-03-3