Clocinnamox (mesylate)

• CAS Number :

  [117332-69-1]

• UNSPSC Description :

  Clocinnamox (mesylate) is a potent opioid antagonist acting at mu, kappa and delta-receptors. Clocinnamox is a selective mu-receptor antagonist than kappa and delta-receptors[1].

• Target Antigen :

  Opioid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein;Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/clocinnamox-mesylate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=C(O2)C([C@]([C@@H]2C(CC3)=O)(CCN4CC5CC5)[C@]3(NC(/C=C/C6=CC=C(Cl)C=C6)=O)[C@H]4C7)=C7C=C1.CS(=O)(O)=O

• Molecular Weight :

  601.11

• References & Citations :

  [1]S D Comer, et, al. Clocinnamox: a novel, systemically-active, irreversible opioid antagonist. J Pharmacol Exp Ther. 1992, 262, 3.|[2]E R Butelman, et, al. Clocinnamox antagonism of opioid suppression of schedule-controlled responding in rhesus monkeys. Psychopharmacology (Berl). 1996, 123, 4.

• Shipping Conditions :

  Room temperature

• Clinical Information :

  No Development Reported