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CCI-006

CAT: 0804-HY-114410-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114410-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells[1].
CAS Number
292053-42-0
Product Name Alternative
8-Nitrotryptanthrin
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCI-006.html
Purity
99.87
Solubility
DMSO : ≥ 83.33 mg/mL
Smiles
O=C(/C(C#N)=C/C1=CC=C(C2=CC=C(S(=O)(N)=O)C=C2)O1)OC
Molecular Formula
C15H12N2O5S
Molecular Weight
332.33
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
MBS5752876CCI-006
A18587-200CCI-006 200mg
A18587-50CCI-006 50mg
A18587-25CCI-006 25mg
A18587-10CCI-006 10mg
A18587-5CCI-006 5mg
A18587-100CCI-006 100mg
A18587-1CCI-006 1mg
A18587-10mM-DCCI-006 10mM * 1mL in DMSO
BA3317-25CCI-007

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