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CNIH2 rabbit pAb

CAT: 0855-ES17349-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES17349-01Size:50 µL
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Background
The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Description
The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
UniProt
Q6PI25
Swiss Prot
Q6PI25
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human CNIH2 AA range: 10-60
Target
CNIH2
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic density . Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells) . .
Gene ID (Human)
254263

UniProtKB · Q6PI25

Protein cornichon homolog 2

CNIH2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q6PI25
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CNIH2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CNIH-2
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneCell projectionEndoplasmic reticulumMembranePostsynaptic cell membraneSynapse

Domain

TransmembraneTransmembrane helix

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