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TRV-120027 TFA

CAT: 0931-TP2158-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2158-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
TRP/TRPV Channel, RAAS, Arrestin
Related Pathways
Endocrinology/Hormones, Membrane transporter/Ion channel, GPCR/G Protein
Purity
0.9745
Bioactivity
TRV-120027 TFA is an angiotensin II–mediated vasoconstriction inhibitor and increases cardiomyocyte contractility. TRV-120027 TFA is a β-arrestin-1-biased AT1R agonist engaging ß-arrestins while blocking G-protein signaling[1]. TRV-120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane.
Smiles
O=C(O)C(F)(F)F.C[C@H](C(O)=O)NC([C@H]1N(C([C@H](CC2=CNC=N2)NC([C@]([C@H](C)CC)([H])NC([C@@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)=O)=O)=O)CCC1)=O
Molecular Formula
C45H68F3N13O12
Molecular Weight
1040.1
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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