TRV-120027 TFA

• Target:

  TRP/TRPV Channel|||RAAS|||Arrestin

• Related Pathways:

  Endocrinology/Hormones|||Membrane transporter/Ion channel|||GPCR/G Protein

• Purity:

  0.9745

• Bioactivity:

  TRV-120027 TFA is an angiotensin II–mediated vasoconstriction inhibitor and increases cardiomyocyte contractility. TRV-120027 TFA is a ?-arrestin-1-biased AT1R agonist engaging ß-arrestins while blocking G-protein signaling[1]. TRV-120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex composed of AT1R–?-arrestin-1–TRPC3–PLC? at the plasma membrane.

• Smiles:

  O=C(O)C(F)(F)F.C[C@H](C(O)=O)NC([C@H]1N(C([C@H](CC2=CNC=N2)NC([C@]([C@H](C)CC)([H])NC([C@@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)=O)=O)=O)CCC1)=O

• Molecular Formula:

  C45H68F3N13O12

• Molecular Weight:

  1040.1

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C