AMG-47a

• Target:

  Kras|||Ras|||JAK|||VEGFR|||p38 MAPK|||Src

• Related Pathways:

  Chromatin/Epigenetic|||MAPK|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Stem Cells

• Purity:

  0.9807

• Bioactivity:

  AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.

• Smiles:

  Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F

• Molecular Formula:

  C29H28F3N5O2

• Molecular Weight:

  535.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  882663-88-9