WZ-3146

• Target:

  EGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling

• Purity:

  0.9895

• Bioactivity:

  WZ3146 is a mutant-selective irreversible inhibitor of EGFR (L858R) and EGFR (E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I) .

• Smiles:

  CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)cc1

• Molecular Formula:

  C24H25ClN6O2

• Molecular Weight:

  464.95

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1214265-56-1