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Pan-Trk-IN-3

CAT: 0931-T64070-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T64070-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others, Apoptosis, Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors, Others, Apoptosis
Bioactivity
Pan-Trk-IN-3 is a potent, broad-spectrum inhibitor of Trk and its drug-resistant mutants, acting on TrkA (IC50: 2 nM), TrkB (IC50: 3 nM), TrkC (IC50: 2 nM), TrkAG595R (IC50: 21 nM), TrkAG667C (IC50: 26 nM), TrkAG667S (IC50: 5 nM), TrkAF589L (IC50: 7 nM) and TrkCG623R (IC50: 6 nM), TrkAG667S (IC50: 5 nM), TrkAF589L (IC50: 7 nM) and TrkCG623R (IC50: 6 nM) . Pan-Trk-IN-3 induces apoptosis and has significant anti-tumour effects.
Molecular Formula
C29H31ClN8O3
Molecular Weight
575.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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