CSF1R-IN-3

CAT: 0931-MF-0019433-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0019433-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2760584-90-3
Target
C-Fms|||CSF-1R
Related Pathways
Tyrosine Kinase/Adaptors
Purity
0.984
Bioactivity
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing effects by inhibiting the migration of macrophages and inducing the reprogramming of M2-type macrophages to M1-type macrophages, thus exhibited activity against colorectal cancer cells.
Smiles
CN1CCN(CC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4cc(NC(=O)Nc5cc(on5)C(C)(C)C)ccc34)c2C)CC1
Molecular Formula
C30H38N8O4
Molecular Weight
574.67
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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