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Prexasertib Mesylate Hydrate

CAT: 0931-T63152-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63152-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1234015-57-6
Target
Apoptosis, Chk, Others
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, Others
Bioactivity
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is an ATP-competitive, selective, second-generation cell cycle checkpoint kinase 1 (CHK1) inhibitor (IC50<1 nM, Ki: 0.9 nM) . It inhibits CHK2 (IC50: 8 nM) and RSK1 (IC50: 9 nM), induces double-stranded DNA breaks and replication mutations, triggers apoptosis, and exhibits potent anti-tumor effects.
Smiles
O.CS(O)(=O)=O.COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Molecular Formula
C19H25N7O6S
Molecular Weight
479.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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