Prexasertib lactate

• Target:

  DNA/RNA Synthesis|||Chk|||Apoptosis

• Related Pathways:

  Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Apoptosis

• Bioactivity:

  Prexasertib lactate is the lactate salt form of Prexasertib and functions as a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of less than 1 nM. It also inhibits CHK2 (IC50 = 8 nM) and RSK1 (IC50 = 9 nM) . This compound induces double-strand DNA breaks and replication stress, leading to apoptosis (cell death), and exhibits antitumor activity.

• Smiles:

  [C@@H] (C (O) =O) (C) O.O (CCCN) C1=C (C (OC) =CC=C1) C2=CC (NC=3C=NC (C#N) =CN3) =NN2

• Molecular Formula:

  C21H25N7O5

• Molecular Weight:

  455.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2781996-46-9