Products for Research Use Only
RegisterLogin

Prexasertib (Mesylate Hydrate)

CAT: 0804-HY-18174BSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-18174BSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of 50=8 nM) and RSK1 (IC50=9 nM) . Prexasertib Mesylate Hydrate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib Mesylate Hydrate shows potent anti-tumor activity[1][2].
CAS Number
1234015-57-6
Product Name Alternative
LY2606368 Mesylate Hydrate; LY2940930
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Apoptosis; Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Prexasertib_Mesylate_Hydrate.html
Solubility
10 mM in DMSO
Smiles
N#CC1=NC=C(NC2=NNC(C3=C(OC)C=CC=C3OCCCN)=C2)N=C1.CS(=O)(O)=O.O
Molecular Formula
C19H25N7O6S
Molecular Weight
479.51
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]King C, et al. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Mol Cancer Ther. 2015 Sep;14 (9) :2004-13.|[2]Yin Y, et al. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res. 2017 Mar 1;7 (3) :473-483.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Chk1; Chk2

Chemical Information

Prexasertib mesylate monohydrate
CAS Number1234015-57-6
PubChem CID46836099
IUPAC Name5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile;methanesulfonic acid;hydrate
Molecular FormulaC19H25N7O6S
Molecular Weight479.5
Topological Polar Surface Area199
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count12
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity592
SMILES
COC1=C(C(=CC=C1)OCCCN)C2=CC(=NN2)NC3=NC=C(N=C3)C#N.CS(=O)(=O)O.O
InChI
InChI=1S/C18H19N7O2.CH4O3S.H2O/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17;1-5(2,3)4;/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25);1H3,(H,2,3,4);1H2
InChIKey
LCYWXOLNJNHLGN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Prexasertib mesylate monohydrate
CAS: 1234015-57-6
CID: 46836099
Formula: C19H25N7O6S
MW: 479.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight479.5
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count12
Rotatable Bond Count8
Exact Mass479.15870272
Monoisotopic Mass479.15870272
Topological Polar Surface Area199 Ų
Heavy Atom Count33
Formal Charge0
Complexity592
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-18174CPrexasertib (mesylate)
HY-17460A-01Garenoxacin (Mesylate hydrate)
HY-122070ATirilazad (mesylate hydrate)
HY-16742B-01Gepotidacin (mesylate hydrate)
HY-15303B-01Pritelivir (mesylate hydrate)
HY-B0750B-01Dolasetron (Mesylate hydrate)
HY-153110A-01Larotinib (mesylate hydrate)
HY-16742BR-01Gepotidacin (mesylate hydrate) (Standard)
HY-17460AR-01Garenoxacin (Mesylate hydrate) (Standard)
HY-B0750BRDolasetron (Mesylate hydrate) (Standard)

Alternative Products

CatalogName
T63152-01Prexasertib Mesylate Hydrate
B2067-5Prexasertib mesylate
T4310L-01Prexasertib lactate hydrate
T72207-01Larotinib mesylate hydrate
MBS577620Dalasetron Mesylate Hydrate
T87534-01Tirilazad mesylate hydrate
MBS3603585-01Garenoxacin mesylate hydrate
GTR19203237-01Pritelivir mesylate hydrate

Popular Products