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CJ-2360

CAT: 931-T63101-01Size: 25 mgDry Ice: NoHazardous: No
25 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2226742-61-4
Target
Others|||ALK
Related Pathways
Others|||Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
CJ-2360 is a potent, orally active ALK inhibitor, capable of acting on wild-type ALK (IC50: 2.2 nM) and F1197M (IC50: 4.0 nM), G1269A (IC50: 8.8 nM), L1196M (IC50: 6.3 nM) and S1206Y ALK mutant (IC50: 8.9 nM) . CJ-2360 strongly inhibited two clinically reported ALK mutants (C1156Y and L1196M) and 468 kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) .
Smiles
O=C1C2=C(N(C(C)C)C=3C1=CC(OC)=C(C3F)N4C[C@H](C)N(C)[C@H](C)C4)NC=5C2=CC=C(C#N)C5
Molecular Formula
C27H30FN5O2
Molecular Weight
475.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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