CJ-2360

• Target:

  Others|||ALK

• Related Pathways:

  Others|||Tyrosine Kinase/Adaptors|||Angiogenesis

• Bioactivity:

  CJ-2360 is a potent, orally active ALK inhibitor, capable of acting on wild-type ALK (IC50: 2.2 nM) and F1197M (IC50: 4.0 nM), G1269A (IC50: 8.8 nM), L1196M (IC50: 6.3 nM) and S1206Y ALK mutant (IC50: 8.9 nM) . CJ-2360 strongly inhibited two clinically reported ALK mutants (C1156Y and L1196M) and 468 kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) .

• Smiles:

  O=C1C2=C (N (C (C) C) C=3C1=CC (OC) =C (C3F) N4C[C@H] (C) N (C) [C@H] (C) C4) NC=5C2=CC=C (C#N) C5

• Molecular Formula:

  C27H30FN5O2

• Molecular Weight:

  475.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2226742-61-4