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KRAS inhibitor-12

CAT: 0931-T62751-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62751-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2230874-00-5
Target
Ras, Kras, Others
Related Pathways
GPCR/G Protein, MAPK, Others
Bioactivity
KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 μM), exhibiting p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50 values of 1.3 and 3.7 μM, respectively. KRAS inhibitor-12 has potential for study in pancreatic, colorectal, and lung cancers.
Smiles
FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C=CC(N)=N4
Molecular Formula
C19H16Cl2FN5OS
Molecular Weight
452.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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