MYF-03-176

• Target:

  YAP

• Related Pathways:

  Stem Cells

• Bioactivity:

  MYF-03-176 is an orally active TEAD1/3/4 inhibitor with IC?? values of 47/32/71 nM, respectively. It also inhibits TEAD transcriptional activity and cell growth in NCI-H226 cells, exhibiting antitumour activity in malignant pleural mesothelioma (MPM) cells with defective Hippo signalling and in mouse xenograft models.

• Smiles:

  O(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2[C@H](NC=3N=CC=CN3)CN(C(C(=C)F)=O)C2

• Molecular Formula:

  C19H18F4N4O2

• Molecular Weight:

  410.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2857937-59-6