MYF-03-69

• Target:

  YAP|||Cell Cycle Arrest|||Apoptosis

• Related Pathways:

  Cell Cycle/Checkpoint|||Apoptosis|||Stem Cells

• Bioactivity:

  MYF-03-69 (TEAD-IN-3) is a covalent and irreversible pan-TEAD inhibitor with IC?? values of 385/143/558/173 nM for TEAD1/TEAD2/TEAD3/TEAD4, respectively. MYF-03-69 inhibits TEAD transcriptional activity (IC?? = 56 nM), upregulates the pro-apoptotic gene BMF, and suppresses mesothelioma cancer cells with defective Hippo signaling, making it suitable for malignant pleural mesothelioma (MPM) .

• Smiles:

  O(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2[C@@H](CN(C(C=C)=O)C2)N3C=C(N=N3)C=4C=CC=NC4

• Molecular Formula:

  C22H20F3N5O2

• Molecular Weight:

  443.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2416418-11-4