MYF-03-69

CAT: 0931-T62597-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T62597-01Size:25 mg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
2416418-11-4
Target
YAP|||Cell Cycle Arrest|||Apoptosis
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis|||Stem Cells
Bioactivity
MYF-03-69 (TEAD-IN-3) is a covalent and irreversible pan-TEAD inhibitor with IC?? values of 385/143/558/173 nM for TEAD1/TEAD2/TEAD3/TEAD4, respectively. MYF-03-69 inhibits TEAD transcriptional activity (IC?? = 56 nM), upregulates the pro-apoptotic gene BMF, and suppresses mesothelioma cancer cells with defective Hippo signaling, making it suitable for malignant pleural mesothelioma (MPM) .
Smiles
O(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2[C@@H](CN(C(C=C)=O)C2)N3C=C(N=N3)C=4C=CC=NC4
Molecular Formula
C22H20F3N5O2
Molecular Weight
443.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Popular Products