DC-LC3in-D5

• Target :

  P62|||Autophagy|||ATG

• Related Pathways :

  Autophagy

• Purity :

  0.9979

• Bioactivity :

  DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B (IC?? = 200 nM), resulting in impaired LC3B lipidation, accumulation of the autophagy substrate p62, and a significant reduction in the formation of autophagosome vesicles.

• Smiles :

  O=C1C(=CNCCN2CCOCC2)C(=O)CC(C=3C=CC=C(Cl)C3Cl)C1

• Molecular Formula :

  C19H22Cl2N2O3

• Molecular Weight :

  397.3

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2868312-73-4