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DC-LC3in-D5

CAT: 0931-T61871-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T61871-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2868312-73-4
Target
P62, Autophagy, ATG
Related Pathways
Autophagy
Purity
0.9979
Bioactivity
DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B (IC50 = 200 nM), resulting in impaired LC3B lipidation, accumulation of the autophagy substrate p62, and a significant reduction in the formation of autophagosome vesicles.
Smiles
O=C1C(=CNCCN2CCOCC2)C(=O)CC(C=3C=CC=C(Cl)C3Cl)C1
Molecular Formula
C19H22Cl2N2O3
Molecular Weight
397.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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