DC-120

CAT: 0931-MF-0145364-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145364-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1261080-40-3
Target
Others
Related Pathways
Others
Bioactivity
DC-120 is an ATP competitive AKT kinase inhibitor that suppressed proliferation and induced apoptosis in liver cancer cells both in vitro and in vivo. DC120 blocked the phosphorylation of downstream molecules in the AKT signal pathway in dose- and time-dependent manners both in vitro and in vivo. DC120 inhibits AKT activity in vitro with an EC (50) of 153 nM. DC120 at 20 mg/kg/day inhibited the CNE2 xenograft tumor growth with a treated group/control group ratio of 38.1%, accompanied by increasing terminal deoxynucleotidyl transferasedUTP nick-end labeling-positive cells in the tumor sample.
Smiles
C(N[C@@H](CC1=C(Cl)C=C(Cl)C=C1)CN)(=O)C=2SC(=NC2)C3=NC(NC)=NC=C3
Molecular Formula
C18H18Cl2N6OS
Molecular Weight
437.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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