EGFR-IN-57

CAT: 0931-T61696-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T61696-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2492382-37-1

Target

Others, Microtubule Associated, Apoptosis, VEGFR, Casein Kinase, EGFR, Topoisomerase

Related Pathways

Stem Cells, Angiogenesis, Apoptosis, Metabolism, DNA Damage/DNA Repair, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, JAK/STAT signaling, Others

Bioactivity

EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR tyrosine kinase (EGFR-TK) inhibitor with an IC50 of 0.054 μM. It also inhibits VEGFR-2, CK2α, topoisomerase IIβ, and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13, and 3.61 μM, respectively. The compound promotes cell cycle arrest at the G2/M and pre-G1 phases and induces apoptosis in cancer cells [1].

Smiles

C(C=1C2=C(C=C3C1C=CC=C3)C=CC=C2)=C4SC(NC=5C=C(C)ON5)=NC4=O

Molecular Formula

C22H15N3O2S

Molecular Weight

385.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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EGFR-IN-57

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