LY-2584702 free base

CAT: 0931-T6159-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T6159-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1082949-67-4

Target

S6 Kinase, mTOR

Related Pathways

PI3K/Akt/mTOR signaling, MAPK

Purity

0.9951

Bioactivity

LY2584702 is a selective, ATP-competitive p70S6K inhibitor (IC50: 4 nM) .

Smiles

CN1C(C2CCN(C3=C4C(=NC=N3)NN=C4)CC2)=NC(=C1)C5=CC(C(F)(F)F)=C(F)C=C5

Molecular Formula

C21H19F4N7

Molecular Weight

445.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Ly-2584702

LY2584702 has been used in trials studying the treatment of Cancer, Advanced Cancer, Renal Cell Carcinoma, Metastases, Neoplasm, and Neuroendocrine Tumors, among others.

CAS Number	1082949-67-4
PubChem CID	25118925
IUPAC Name	4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo[5,4-d]pyrimidine
Molecular Formula	C21H19F4N7
Molecular Weight	445.4
XLogP	3.6
Topological Polar Surface Area	75.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Heavy Atom Count	32
Formal Charge	0
Complexity	644

SMILES

CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F

InChI

InChI=1S/C21H19F4N7/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30)

InChIKey

FYXRSVDHGLUMHB-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1082949-67-4

CID: 25118925

Formula: C21H19F4N7

MW: 445.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	445.4
XLogP3	3.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Exact Mass	445.16380628
Monoisotopic Mass	445.16380628
Topological Polar Surface Area	75.5 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	644
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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GTR19193595-01	LY-79771 free base
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LY-2584702 free base

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