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Sulindac sodium

CAT: 0931-T61585-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61585-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
63804-15-9
Target
Others, NF-κB, PD-1/PD-L1
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, Others, Immunology/Inflammation, NF-κB
Bioactivity
Sulindac (sodium) (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac (sodium) is used to reduce pain, swelling, and joint stiffness from arthritis. Sulindac is also used for the research of arthritis of the spine, gouty arthritis. Sulindac (sodium), as an immunomodulatory agent, can downregulate PD-L1 through the blockade of NF-κB signaling and modulates the response of pMMR colorectal cancer (CRC) to anti-PD-L1 immunotherapy, inhibits the development and progression of colorectal cancer CRC. Sulindac (sodium) also inhibits TGF-β1- induced epithelial-mesenchymal transition (EMT) and suppresses lung cancer cell migration and invasion via downregulation of SIRT1 [1] [2].
Smiles
[Na+].CC1=C(CC([O-])=O)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)=O
Molecular Formula
C20H16FNaO3S
Molecular Weight
378.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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