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Sulindac (sodium)

CAT: 0804-HY-B0008ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0008ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sulindac (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac also is an immunomodulatory agent. Sulindac can be used for the research of arthritis of the spine, gouty arthritis and kinds of cancer including colorectal cancer (CRC) and lung cancer[1][2].
CAS Number
63804-15-9
Product Name Alternative
MK-231 (sodium)
UNSPSC
12352005
Target
NF-κB; PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sulindac-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(CC(C1=C2C=CC(F)=C1)=C(/C2=C/C3=CC=C(C=C3)S(C)=O)C)O[Na]
Molecular Formula
C20H16FNaO3S
Molecular Weight
378.39
References & Citations
[1]Byong-Ki Cha, et al. Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1. Oncotarget. 2016 Aug 30;7 (35) :57213-57227.|[2]Bin Yi, et al. Sulindac Modulates the Response of Proficient MMR Colorectal Cancer to Anti-PD-L1 Immunotherapy. Mol Cancer Ther. 2021 Jul;20 (7) :1295-1304.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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