Sulindac

• Target:

  NF-?B|||PD-1/PD-L1|||COX|||Autophagy

• Related Pathways:

  Cell Cycle/Checkpoint|||Neuroscience|||NF-?B|||Autophagy|||Apoptosis|||Immunology/Inflammation

• Purity:

  0.9949

• Bioactivity:

  Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.

• Smiles:

  C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(S(C)=O)C=C3

• Molecular Formula:

  C20H17FO3S

• Molecular Weight:

  356.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  38194-50-2