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Sulindac

CAT: 0931-T0459-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0931-T0459-01Size:50 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
38194-50-2
Target
NF-?B|||PD-1/PD-L1|||COX|||Autophagy
Related Pathways
Cell Cycle/Checkpoint|||Neuroscience|||NF-?B|||Autophagy|||Apoptosis|||Immunology/Inflammation
Purity
0.9949
Bioactivity
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.
Smiles
C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(S(C)=O)C=C3
Molecular Formula
C20H17FO3S
Molecular Weight
356.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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