PHA-665752

CAT: 0931-T6128-02Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No

1 / 1

CAT#:0931-T6128-02Size:1 mL - 10 mM (in DMSO)

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

477575-56-7

Target

C-Met/HGFR, Autophagy, Apoptosis, FGFR, VEGFR, Bcr-Abl

Related Pathways

Tyrosine Kinase/Adaptors, Autophagy, Angiogenesis, Cytoskeletal Signaling, Apoptosis

Purity

0.9935

Bioactivity

PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.

Smiles

C(=C\1/C=2C(NC1=O)=CC=C(S(CC3=C(Cl)C=CC=C3Cl)(=O)=O)C2)\C4=C(C)C(C(=O)N5[C@@H](CN6CCCC6)CCC5)=C(C)N4

Molecular Formula

C32H34Cl2N4O4S

Molecular Weight

641.61

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

(3Z)-5-(((2,6-Dichlorophenyl)methyl)sulfonyl)-3-((3,5-dimethyl-4-(((2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one

PHA-665752 is a member of the class of indolones that is 1,3-dihydro-2H-indol-2-one which is substituted by a (2,6-dichlorobenzyl)sulfonyl group at position 5 and by a (1H-pyrrol-2-yl)methylidene group at position 2, the pyrrole ring of which is substituted by methyl groups at positions 3 and 5, and by a [2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl group at position 4 (the Z,R isomer). It has a role as an antineoplastic agent and a c-Met tyrosine kinase inhibitor. It is a secondary carboxamide, a tertiary carboxamide, a dichlorobenzene, a member of indolones, a sulfone, a N-acylpyrrolidine, a pyrrolecarboxamide and an enamide.

CAS Number	477575-56-7
PubChem CID	10461815
IUPAC Name	(3Z)-5-[(2,6-dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one
Molecular Formula	C32H34Cl2N4O4S
Molecular Weight	641.6
XLogP	5
Topological Polar Surface Area	111
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Heavy Atom Count	43
Formal Charge	0
Complexity	1180

SMILES

CC1=C(NC(=C1C(=O)N2CCC[C@@H]2CN3CCCC3)C)/C=C\4/C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O

InChI

InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1

InChIKey

OYONTEXKYJZFHA-SSHUPFPWSA-N

Chemical Structure

2D Structure

CAS: 477575-56-7

CID: 10461815

Formula: C32H34Cl2N4O4S

MW: 641.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	641.6
XLogP3	5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	640.1677821
Monoisotopic Mass	640.1677821
Topological Polar Surface Area	111 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	1180
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T24629-01	PHA-408
T6338-01	PHA-680632
T61987-01	PHA 568487
T19657-01	PHA-690509
T6206-01	PHA-767491
T2113-01	PHA-793887
T23145-01	PHA 543613
T69296-01	PHA-680626
T33959-01	PHA-782584
T6940-01	PHA-767491 hydrochloride

Alternative Products

Catalog	Name
A2307-5.1	PHA-665752
abx076781-01	PHA 665752

PHA-665752

Chemical Information

Related Products

Alternative Products

Popular Products