B-Raf IN 7

• Target:

  Others|||Raf

• Related Pathways:

  MAPK|||Others

• Bioactivity:

  B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor with an IC50 of 110.23 nM. It exhibits antitumor activity against colon carcinoma cells (HCT-116), mammary gland cells (MCF-7), hepatocellular carcinoma cells (HEPG-2), human cervical carcinoma cells (Hela), and human prostate cancer cells (PC-3), with IC50 values of 7.50, 9.87, 10.57, 11.63, and 12.83 ?M, respectively [1].

• Smiles:

  NC=1N (N=NC1C (OCC) =O) C2=CC=C (C=C2) C=3CCC (=O) NN3

• Molecular Formula:

  C15H16N6O3

• Molecular Weight:

  328.33

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2477725-07-6