THK-5117

• Target:

  Microtubule Associated|||Others

• Related Pathways:

  Others|||Cytoskeletal Signaling

• Bioactivity:

  THK-5117 is an arylquinoline derivative with the potential as a PET probe for tau imaging. THK-5117 shows high binding affinity to tau fibrils with a Ki value of 10.5 nM. THK-5117 also shows high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates [1].

• Smiles:

  O(CC(CF)O)C1=CC2=C(N=C(C=C2)C3=CC=C(NC)C=C3)C=C1

• Molecular Formula:

  C19H19FN2O2

• Molecular Weight:

  326.36

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1374107-54-6