TC-5115

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  TC-5115 is a potent inhibitor of MLL methyltransferase with IC50 value of 16 nM. TC-5115 may lead to the development of a new therapy for the treatment of human MLL leukemia. The mixed-lineage leukemia (MLL) protein, also known as MLL1, is a lysine methyltransferase specifically responsible for methylation of histone 3 lysine 4. MLL has been pursued as an attractive therapeutic target for the treatment of acute leukemia carrying the MLL fusion gene or MLL leukemia.

• Smiles:

  O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CN(CC4CN(CC5=CC=CS5)C4)CC[C@@H](C(O)=O)N)[C@H]1O

• Molecular Formula:

  C23H32N8O5S

• Molecular Weight:

  532.62

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2458182-10-8