CREBBP Recombinant Rabbit Monoclonal Antibody [PS01-16]

CREBBP Recombinant Rabbit Monoclonal Antibody [PS01-16]

• Description: Cyclic adenosine monophosphate Response Element Binding protein Binding Protein (CREB-binding protein), also known as CREBBP or CBP or KAT3A, is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3. CBP has intrinsic acetyltransferase functions; it is able to add acetyl groups to both transcription factors as well as histone lysines, the latter of which has been shown to alter chromatin structure making genes more accessible for transcription. This relatively unique acetyltransferase activity is also seen in another transcription enzyme, EP300 (p300). Together, they are known as the p300-CBP coactivator family and are known to associate with more than 16,000 genes in humans; however, while these proteins share many structural features, emerging evidence suggests that these two co-activators may promote transcription of genes with different biological functions. For example, CBP alone has been implicated in a wide variety of pathophysiologies including colorectal cancer as well as head and neck squamous cell carcinoma. In these diseases, association of CBP with β-catenin has been shown to promote cancer cell proliferation and disease aggressiveness, whereas p300/ β-catenin leads to cell differentiation and/ or apoptosis. CBP has also been shown to help modulate liver function via maintenance of energy homeostasis in response to changes in cell nutrition conditions by regulating the activity of transcription factors and genes responsible for lipogenesis and gluconeogenesis. CBP is also implicated in the etiologies of several other diseases including hematologic malignancies and other solid tumors, diabetes, schizophrenia, Alzheimer's Disease, depression, and many other neurological conditions.
• Product Name Alternative: CBP antibody CBP_HUMAN antibody CREB binding protein antibody CREB-binding protein antibody Crebbp antibody Cyclic AMP responsive enhancer binding protein antibody KAT3A antibody RSTS antibody RTS antibody Rubinstein Taybi syndrome antibody
• Abbreviation: CREBBP, CBP
• CAS Number: 9000-83-3
• Swiss Prot: Q92793 Human, P45481 Mouse
• Cellular Locus: Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide.
• Isotype: IgG
• Clone: PS01-16
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IHC-P
• Positive Control: Human colon carcinoma tissue, human breast carcinoma tissue, mousse testis tissue.
• Concentration: 1 mg/mL
• Dilution: IHC-P: 1:200-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 265 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes