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CREBBP Rabbit Polyclonal Antibody

CAT: 0992-HA500056Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500056Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region . Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway.
CAS Number
9007-83-4
Product Name Alternative
CBP antibody CBP_HUMAN antibody CREB binding protein antibody CREB-binding protein antibody Crebbp antibody Cyclic AMP responsive enhancer binding protein antibody KAT3A antibody RSTS antibody RTS antibody Rubinstein Taybi syndrome antibody
Abbreviation
CREBBP CBP
Swiss Prot
Q92793 Human, P45481 Mouse
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within C-terminal human CREBBP.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Human lung carcinoma tissue, mouse cerebellum tissue, rat bladder tissue, rat colon tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IHC-P: 1:500-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size:265 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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