CREBBP Rabbit Polyclonal Antibody

CREBBP Rabbit Polyclonal Antibody

• Description: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region . Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway.
• Product Name Alternative: CBP antibody CBP_HUMAN antibody CREB binding protein antibody CREB-binding protein antibody Crebbp antibody Cyclic AMP responsive enhancer binding protein antibody KAT3A antibody RSTS antibody RTS antibody Rubinstein Taybi syndrome antibody
• Abbreviation: CREBBP CBP
• CAS Number: 9007-83-4
• Swiss Prot: Q92793 Human, P45481 Mouse
• Cellular Locus: Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within C-terminal human CREBBP.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Human lung carcinoma tissue, mouse cerebellum tissue, rat bladder tissue, rat colon tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:500-1:1,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size:265 kDa.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No