25-Hydroxycholesterol

• Target:

  HMG-CoA Reductase|||Endogenous Metabolite

• Related Pathways:

  Metabolism

• Purity:

  0.9989

• Bioactivity:

  25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs) . It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50?65 nM) and selective suppressor of IgA production by B cells.

• Smiles:

  C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

• Molecular Formula:

  C27H46O2

• Molecular Weight:

  402.65

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2140-46-7