TP-3654

CAT: 0931-T4523-03Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No

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CAT#:0931-T4523-03Size:1 mL - 10 mM (in DMSO)

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1361951-15-6

Target

Pim

Related Pathways

Chromatin/Epigenetic, JAK/STAT signaling

Purity

0.9995

Bioactivity

TP-3654, a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM) .

Smiles

CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1

Molecular Formula

C22H25F3N4O

Molecular Weight

418.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

2-((1r,4r)-4-((3-(3-(Trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol

Nuvisertib is an orally available, second-generation and selective ATP-competitive inhibitor of proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, nuvisertib selectively binds to and prevents the activation of the PIM kinases. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIM. PIMs, constitutively active proto-oncogenic serine/threonine kinases, are upregulated in various types of cancers and play key roles in tumor cell proliferation and survival.

CAS Number	1361951-15-6
PubChem CID	66598080
IUPAC Name	2-[4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]cyclohexyl]propan-2-ol
Molecular Formula	C22H25F3N4O
Molecular Weight	418.5
XLogP	4.6
Topological Polar Surface Area	62.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Heavy Atom Count	30
Formal Charge	0
Complexity	579

SMILES

CC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)O

InChI

InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)

InChIKey

XRNVABDYQLHODA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1361951-15-6

CID: 66598080

Formula: C22H25F3N4O

MW: 418.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	418.5
XLogP3	4.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	418.19804592
Monoisotopic Mass	418.19804592
Topological Polar Surface Area	62.5 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	579
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
527505	TP-3654
A20584-100	TP-3654 100mg
A20584-50	TP-3654 50mg
A20584-25	TP-3654 25mg
HY-101126R	TP-3654 (Standard)
A20584-5	TP-3654 5mg

TP-3654

Chemical Information

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