CAY10608

• Target :

  Others|||Potassium Channel|||iGluR

• Related Pathways :

  Others|||Membrane transporter/Ion channel|||Neuroscience

• Bioactivity :

  N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM) . It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on ?-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors. CAY10608 is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, CAY10608, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion.

• Smiles :

  N(S(C)(=O)=O)C1=CC=C(OC[C@H](CNCCC2=CC(Cl)=C(Cl)C=C2)O)C=C1

• Molecular Formula :

  C18H22Cl2N2O4S

• Molecular Weight :

  433.35

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  457897-92-6