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CAY10602

CAT: 0013-GTR19159537-07Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159537-07Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
CAS Number
374922-43-7
Product Name Alternative
CAY10602 | CAY-10602 | CAY 10602
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL 238.98 mM
Smiles
Fc1ccc (cc1) n1c2nc3ccccc3nc2c (c1N) S (=O) (=O) c1ccccc1
Molecular Formula
C22H15FN4O2S
Molecular Weight
418.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (4-fluorophenyl) -3- (phenylsulfonyl) -1H-pyrrolo[2,3-b]quinoxalin-2-amine

Chemical Information

1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
CAS Number374922-43-7
PubChem CID1915791
IUPAC Name3-(benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine
Molecular FormulaC22H15FN4O2S
Molecular Weight418.4
XLogP4.5
Topological Polar Surface Area99.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count30
Formal Charge0
Complexity702
SMILES
C1=CC=C(C=C1)S(=O)(=O)C2=C(N(C3=NC4=CC=CC=C4N=C23)C5=CC=C(C=C5)F)N
InChI
InChI=1S/C22H15FN4O2S/c23-14-10-12-15(13-11-14)27-21(24)20(30(28,29)16-6-2-1-3-7-16)19-22(27)26-18-9-5-4-8-17(18)25-19/h1-13H,24H2
InChIKey
CSFVFDHRYKBBPD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
CAS: 374922-43-7
CID: 1915791
Formula: C22H15FN4O2S
MW: 418.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight418.4
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass418.08997507
Monoisotopic Mass418.08997507
Topological Polar Surface Area99.3 Ų
Heavy Atom Count30
Formal Charge0
Complexity702
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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530654CAY10602
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