FRM-024

CAT: 0931-T39492Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T39492Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2085780-87-4

Target

Others, Gamma-secretase

Related Pathways

Proteases/Proteasome, Neuroscience, Others, Stem Cells

Bioactivity

FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment of familial Alzheimer's disease.

Smiles

COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C2CC2)[C@@H](N1)c1ccc(Cl)cc1 |t:16,@:18|

Molecular Formula

C22H22ClN5O2

Molecular Weight

423.9

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

(5R,6S)-5-(4-chlorophenyl)-6-cyclopropyl-3-[6-methoxy-5-(4-methylimidazol-1-yl)-2-pyridinyl]-5,6-dihydro-2H-1,2,4-oxadiazine

CAS Number	2085780-87-4
PubChem CID	126599752
IUPAC Name	(5R,6S)-5-(4-chlorophenyl)-6-cyclopropyl-3-[6-methoxy-5-(4-methylimidazol-1-yl)-2-pyridinyl]-5,6-dihydro-2H-1,2,4-oxadiazine
Molecular Formula	C22H22ClN5O2
Molecular Weight	423.9
XLogP	3.8
Topological Polar Surface Area	73.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	30
Formal Charge	0
Complexity	625

SMILES

CC1=CN(C=N1)C2=C(N=C(C=C2)C3=N[C@@H]([C@@H](ON3)C4CC4)C5=CC=C(C=C5)Cl)OC

InChI

InChI=1S/C22H22ClN5O2/c1-13-11-28(12-24-13)18-10-9-17(25-22(18)29-2)21-26-19(14-5-7-16(23)8-6-14)20(30-27-21)15-3-4-15/h5-12,15,19-20H,3-4H2,1-2H3,(H,26,27)/t19-,20+/m1/s1

InChIKey

IOQORVDNYPOZPL-UXHICEINSA-N

Chemical Structure

2D Structure

CAS: 2085780-87-4

CID: 126599752

Formula: C22H22ClN5O2

MW: 423.9

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	423.9
XLogP3	3.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	423.1462027
Monoisotopic Mass	423.1462027
Topological Polar Surface Area	73.6 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	625
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T26666-01	ASM-024
T13065-01	TAK-024
T77488-01	GFB-024
T61071-01	AX-024
T41162-01	ZLN 024 hydrochloride
T18688-01	SNIPER (ABL) -024
T4403-01	AX-024 hydrochloride
T203748-01	WWL-0245
T12054-01	MK-0249
T85352-01	NT-0249

Alternative Products

Catalog	Name
HY-115726-01	FRM-024
HY-115726A-01	(-) -FRM-024
VEC54473-01	AX-024
255469	HS 024
MBS5767690	TAK-024
BUP20378-01	GFB-024
C04786	TP-024
HY-116167	RY 024
MBS5776394	ASM-024
MBS3605766-01	ZLN-024

FRM-024

Chemical Information

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