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CAY10503

CAT: 0931-T36963-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T36963-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
890854-82-7
Target
Apoptosis, Others
Related Pathways
Others, Apoptosis
Bioactivity
CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of 7.0, 23, and 20 μM, respectively. Accumulation of HL60 cells in G0-G1 occurred within eight hours following treatment with 50 μM CAY10503, whereas 10 μM CAY10503 required 96 hours for cell cycle arrest to appear. CAY10503 also induces differentiation of HL60 cells into the following positive cells: CD14 (monocytic marker) as well as CD11b and CD11c (granulocytic markers) . Approximately 60% of HL60 cells exposed to 10 μM CAY10503 expressed these markers within 72 hours.
Smiles
OC=1C=C(C=C(O)C1)C2=CC=C(C=C2)C3=CC=C(O)C=C3
Molecular Formula
C18H14O3
Molecular Weight
278.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

5-[4-(4-Hydroxyphenyl)phenyl]benzene-1,3-diol
CAS Number890854-82-7
PubChem CID11630507
IUPAC Name5-[4-(4-hydroxyphenyl)phenyl]benzene-1,3-diol
Molecular FormulaC18H14O3
Molecular Weight278.3
XLogP4.1
Topological Polar Surface Area60.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity306
SMILES
C1=CC(=CC=C1C2=CC=C(C=C2)O)C3=CC(=CC(=C3)O)O
InChI
InChI=1S/C18H14O3/c19-16-7-5-13(6-8-16)12-1-3-14(4-2-12)15-9-17(20)11-18(21)10-15/h1-11,19-21H
InChIKey
DADMQAUVBPTTDT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-[4-(4-Hydroxyphenyl)phenyl]benzene-1,3-diol
CAS: 890854-82-7
CID: 11630507
Formula: C18H14O3
MW: 278.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight278.3
XLogP34.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass278.094294304
Monoisotopic Mass278.094294304
Topological Polar Surface Area60.7 Ų
Heavy Atom Count21
Formal Charge0
Complexity306
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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