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12 (S) -HETrE

CAT: 0931-T36773-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0931-T36773-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
72710-10-2
Target
Integrin, Others, Endogenous Metabolite, PKA
Related Pathways
Metabolism, Cytoskeletal Signaling, Others, Tyrosine Kinase/Adaptors
Bioactivity
12 (S) -HETrE is an endogenous metabolite produced by oxidation of ω-6 PUFA dihomo-γ-linolenic acid (DGLA) by 12-lipoxygenase (12-LOX) in platelets, which acts on Gαs-coupled G-protein-coupled receptors, has antithrombotic properties, and has potential therapeutic use in cardiovascular disease. 12 (S) -HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.
Smiles
C(\[C@H](C/C=C\CCCCC)O)=C/C=C\CCCCCCC(O)=O
Molecular Formula
C20H34O3
Molecular Weight
322.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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