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12 (S) -HpETE

CAT: 0931-T37969-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0931-T37969-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
71774-10-2
Target
DNA/RNA Synthesis, Endogenous Metabolite, Others
Related Pathways
Others, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Metabolism
Bioactivity
12 (S) -HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LOE. 12 (S) -HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.
Smiles
[C@@H](/C=C/C=C\C/C=C\CCCC(O)=O)(C/C=C\CCCCC)OO
Molecular Formula
C20H32O4
Molecular Weight
336.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C