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XStAx-VHLL

CAT: 0931-T36275Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0931-T36275Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PROTACs, APC/C, Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling, Stem Cells, PROTAC, Cell Cycle/Checkpoint
Bioactivity
Selective peptide-based β-catenin Degrader. Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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