XStAx-VHLL

CAT: 0931-MF-0046959Size: 100 µgDry Ice: NoHazardous: No
CAT#:0931-MF-0046959Size:100 µg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs|||APC/C|||Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling|||Stem Cells|||PROTAC|||Cell Cycle/Checkpoint
Bioactivity
Selective peptide-based ?-catenin Degrader. Comprises a ?-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces ?-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades ?-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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