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XStAx-VHLL

CAT: 0804-HY-P5819-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P5819-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity[1].
UNSPSC
12352209
Target
PROTACs; Wnt; β-catenin
Type
Peptides
Related Pathways
PROTAC; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xstax-vhll.html
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H](CCCNC(N)=N)NC(C)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N3CCC[C@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@H]4CC(O)=O)=O)=O)=O)(CCC/C=C/CCC[C@@](C(N[C@@H](CC5=CN=CN5)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CNC7=C6C=CC=C7)C(N[C@@H](CCCNC(N)=N)C(NCCCCCC(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N8[C@H](C(N[C@@H](CC9=CC=C(C=C9)O)C(N[C@@H]([C@@H](C)CC)C(N%10[C@H](C(N)=O)CCC%10)=O)=O)=O)CCC8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)(NC4=O)C)C)=O)=O)=O)=O
Molecular Formula
C154H244N48O29
Molecular Weight
3231.89
References & Citations
[1]Liao H, et al. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discov. 2020 Jun 9;6:35.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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