VHL-IN-1

• Target :

  Ligand for E3 Ligase|||HIF/HIF Prolyl-Hydroxylase

• Related Pathways :

  Metabolism|||PROTAC|||Chromatin/Epigenetic

• Bioactivity :

  VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1? and enhances its transcriptional activity. It shows promise for applications as a HIF-1? stabilizer and for the degradation of proteolytically targeted chimeras (PROTACs) [1].

• Molecular Formula :

  C28H37FN4O4S

• Molecular Weight :

  544.68

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C