CAY10746

CAT: 0931-T36196-02Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No

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CAT#:0931-T36196-02Size:1 mL - 10 mM (in DMSO)

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2247240-76-0

Target

ROCK

Related Pathways

Stem Cells, Cell Cycle/Checkpoint, Cytoskeletal Signaling

Purity

0.9971

Bioactivity

CAY10746 is a selective Rho kinase (ROCK) inhibitor, targeting ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be employed in the study of diabetic retinopathy.

Smiles

CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1

Molecular Formula

C26H23N3O5

Molecular Weight

457.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

CID 155513187

CAS Number	2247240-76-0
PubChem CID	155513187
IUPAC Name	4-(dimethylamino)-N-[3-[[2-(4-oxochromen-7-yl)oxyacetyl]amino]phenyl]benzamide
Molecular Formula	C26H23N3O5
Molecular Weight	457.5
XLogP	3.4
Topological Polar Surface Area	97
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Heavy Atom Count	34
Formal Charge	0
Complexity	762

SMILES

CN(C)C1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC(=O)COC3=CC4=C(C=C3)C(=O)C=CO4

InChI

InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32)

InChIKey

WVGDUQVQWLHVEA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2247240-76-0

CID: 155513187

Formula: C26H23N3O5

MW: 457.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	457.5
XLogP3	3.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	457.16377084
Monoisotopic Mass	457.16377084
Topological Polar Surface Area	97 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	762
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T37466-01	CAY10766
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T36195-01	CAY10744
T36197-01	CAY10747
T36194-01	CAY10726
T36461-01	CAY10748
T37465-01	CAY10742
T36702-01	CAY10753
T37355-01	CAY10703

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M34824-01	CAY10746

CAY10746

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