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CAY10748

CAT: 0931-T36461-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0931-T36461-01Size:500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2412902-55-5
Target
Others
Related Pathways
Others
Bioactivity
CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 ?M in a competition binding assay) .1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 ?M, respectively, in a reporter assay) . It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-? and the levels of chemokine (C-X-C motif) ligand 10 (CXCL10), and IL-6 in peripheral blood mononuclear cells (PBMCs) when used at a concentration of 10 ?M. It also reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 0.15, but not 1.5, mg/kg.
Smiles
C(CCNC(OCC1=CC=CC=C1)=O)N2C=3C(N=C2NC(=O)C=4N(CC)N=C(C)C4)=CC(C(N)=O)=CC3OCCCOC
Molecular Formula
C30H37N7O6
Molecular Weight
591.66
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS5802516CAY10748

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