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CAY10744

CAT: 0931-T36195-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T36195-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2375613-31-1
Target
Topoisomerase|||Others
Related Pathways
Others|||DNA Damage/DNA Repair
Bioactivity
CAY10744 is a topoisomerase II-? poison.1 It inhibits topoisomerase II-? by 78.9% when used at a concentration of 20 ?M. CAY10744 is selective for topoisomerase II-? over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 ?M. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 ?M, respectively) . CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 ?M. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.
Smiles
OC1=C2CC=3C(C2=CC=C1)=NC(=CC3C4=CC=C(O)C=C4)C5=C(Cl)C=CC=C5
Molecular Formula
C24H16ClNO2
Molecular Weight
385.84
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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