12 (R) -HETE

• Target:

  Others|||Aryl Hydrocarbon Receptor|||ATPase

• Related Pathways:

  Immunology/Inflammation|||Membrane transporter/Ion channel|||Others

• Bioactivity:

  Biosynthesis of 12 (R) -HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12 (R) -HETE can be produced by 12 (R) -LOs and also by CYP450 oxidation. The activity of 12 (R) -HETE in mammals is predominantly proinflammatory. 12 (R) -HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits.

• Smiles:

  C(\[C@@H](C/C=C\CCCCC)O)=C/C=C\C/C=C\CCCC(O)=O

• Molecular Formula:

  C20H32O3

• Molecular Weight:

  320.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  82337-46-0