DHP-B

• Description :

  DHP-B possesses anti-cancer activity and induces apoptosis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial CPT1A-VDAC1 interaction, leading to increased mitochondrial permeability and reduced oxygen consumption and energy metabolism in CRC cells. DHP-B can be isolated from the plant Peperomia dindygulensis[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dhp-b.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=C2C(OCO2)=CC([C@@H](C3=CC(OC)=C(OC)C(OC)=C3)[C@@]4([H])COC(C4=C)=O)=C1

• Molecular Formula :

  C23H24O8

• Molecular Weight :

  428.43

• References & Citations :

  [1]Anni Hu, A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer. Redox Biol. 2023 Dec:68:102959.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported