DHP-B

• Description:

  DHP-B possesses anti-cancer activity and induces apoptosis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial CPT1A-VDAC1 interaction, leading to increased mitochondrial permeability and reduced oxygen consumption and energy metabolism in CRC cells. DHP-B can be isolated from the plant Peperomia dindygulensis[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dhp-b.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C2C (OCO2) =CC ([C@@H] (C3=CC (OC) =C (OC) C (OC) =C3) [C@@]4 ([H]) COC (C4=C) =O) =C1

• Molecular Formula:

  C23H24O8

• Molecular Weight:

  428.43

• References & Citations:

  [1]Anni Hu, A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer. Redox Biol. 2023 Dec:68:102959.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported