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DHP-B

CAT: 0804-HY-161027Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161027Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHP-B possesses anti-cancer activity and induces apoptosis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial CPT1A-VDAC1 interaction, leading to increased mitochondrial permeability and reduced oxygen consumption and energy metabolism in CRC cells. DHP-B can be isolated from the plant Peperomia dindygulensis[1].
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhp-b.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C(OCO2)=CC([C@@H](C3=CC(OC)=C(OC)C(OC)=C3)[C@@]4([H])COC(C4=C)=O)=C1
Molecular Formula
C23H24O8
Molecular Weight
428.43
References & Citations
[1]Anni Hu, A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer. Redox Biol. 2023 Dec:68:102959.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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