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SC-2001

CAT: 0931-T28697-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T28697-03Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1383727-17-0
Target
Others, STAT, Apoptosis, Bcl-2 Family
Related Pathways
Stem Cells, JAK/STAT signaling, Apoptosis, Others
Bioactivity
SC-2001 is a MCL-1 inhibitor. SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma.
Smiles
C(C=1NC(C2=CC=3C(N2)=CC=C(Br)C3)=CC1OC)=C4C=CC=N4
Molecular Formula
C18H14BrN3O
Molecular Weight
368.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(2E)-5-bromo-2-[(5Z)-4-methoxy-5-(1H-pyrrol-2-ylmethylidene)pyrrol-2-ylidene]indole
CAS Number1383727-17-0
PubChem CID178202106
IUPAC Name(2E)-5-bromo-2-[(5Z)-4-methoxy-5-(1H-pyrrol-2-ylmethylidene)pyrrol-2-ylidene]indole
Molecular FormulaC18H14BrN3O
Molecular Weight368.2
XLogP2.9
Topological Polar Surface Area49.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity765
SMILES
COC\1=C/C(=C\2/C=C3C=C(C=CC3=N2)Br)/N/C1=C\C4=CC=CN4
InChI
InChI=1S/C18H14BrN3O/c1-23-18-10-16(22-17(18)9-13-3-2-6-20-13)15-8-11-7-12(19)4-5-14(11)21-15/h2-10,20,22H,1H3/b16-15+,17-9-
InChIKey
HQULZCASURMKEF-LVRQTRGPSA-N
Chemical Structure
2D Structure
2D structure of (2E)-5-bromo-2-[(5Z)-4-methoxy-5-(1H-pyrrol-2-ylmethylidene)pyrrol-2-ylidene]indole
CAS: 1383727-17-0
CID: 178202106
Formula: C18H14BrN3O
MW: 368.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.2
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass367.03202
Monoisotopic Mass367.03202
Topological Polar Surface Area49.4 Ų
Heavy Atom Count23
Formal Charge0
Complexity765
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-120113-01SC-2001
sc-507307SC 2001
JLB08913-01SKL 2001
HY-150650S07-2001
sc-65463HHV-6 (2001)
sc-51694SC (SC-05)
MD023023-12SC-PEG12-SC
HO023023-1K-01SC-PEG-SC, 1K
HO023023-4K-01SC-PEG-SC, 4K
HO023023-500-01SC-PEG-SC, 500

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