ONO-8809

• Target :

  Others|||Histamine Receptor

• Related Pathways :

  GPCR/G Protein|||Immunology/Inflammation|||Neuroscience|||Others

• Bioactivity :

  ONO-8809 is a thromboxane A2 receptor antagonist. ONO-8809 inhibited the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner. Macrophage accumulation and matrix metalloproteinase-9 (MMP-9) activity in the stroke-negative area in the contralateral cerebral cortex to the stroke lesion of salt-loaded SHRSP and 8-iso-PGF2alpha-treated SHRSP were significantly reduced by ONO-8809 treatment.

• Smiles :

  C(NS(=O)(=O)C1=CC=C(Br)C=C1)[C@H]2[C@H](/C=C\CCCC(OCCCCCCCCCC)=O)[C@@]3(C[C@]2(CC3)[H])[H]

• Molecular Formula :

  C30H46BrNO4S

• Molecular Weight :

  596.66

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  123288-47-1