Binimetinib

CAT: 0931-T2508-04Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T2508-04Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

606143-89-9

Target

MEK, Autophagy

Related Pathways

Autophagy, MAPK

Purity

>99.99%

Bioactivity

Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity for the treatment of metastatic melanoma that cannot be resected or has a BRAF V600E or V600K mutation.

Smiles

Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(cc12)C(=O)NOCCO

Molecular Formula

C17H15BrF2N4O3

Molecular Weight

441.23

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Binimetinib

Binimetinib is a member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of benzimidazoles, a member of bromobenzenes, a secondary amino compound, a hydroxamic acid ester and a member of monofluorobenzenes.

CAS Number	606143-89-9
PubChem CID	10288191
IUPAC Name	6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
Molecular Formula	C17H15BrF2N4O3
Molecular Weight	441.2
XLogP	3.1
Topological Polar Surface Area	88.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Heavy Atom Count	27
Formal Charge	0
Complexity	521

SMILES

CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

InChI

InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChIKey

ACWZRVQXLIRSDF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 606143-89-9

CID: 10288191

Formula: C17H15BrF2N4O3

MW: 441.2

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	441.2
XLogP3	3.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	440.02956
Monoisotopic Mass	440.02956
Topological Polar Surface Area	88.4 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	521
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
bs-83020C-01	Binimetinib
HY-15202S1-01	Binimetinib-d3
C12377-1g	Binimetinib (MEK162)
AR-B07254-01	Binimetinib Glucuronide
HY-15202S3	Binimetinib-d4
HY-15202R-01	Binimetinib (Standard)
TRC-B655730-250MG	Binimetinib Hydroxylamine
SD5951-10mM	Binimetinib (MEK inhibitor)
TRC-N890670-5MG	N-Nitroso Binimetinib

Binimetinib

Chemical Information

Alternative Products

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